Cognitive Dysfunction in Schizophrenia
نویسندگان
چکیده
منابع مشابه
Molecular targets for treating cognitive dysfunction in schizophrenia.
Cognitive impairment is a core feature of schizophrenia as deficits are present in the majority of patients, frequently precede the onset of other positive symptoms, persist even with successful treatment of positive symptoms, and account for a significant portion of functional impairment in schizophrenia. While the atypical antipsychotics have produced incremental improvements in the cognitive...
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Cognitive deficits, including impairments in working memory that have been linked to the prefrontal cortex, are among the most debilitating and difficult to treat features of schizophrenia. Consequently, the identification of potential targets informed by the pathophysiology of the illness is needed to develop novel pharmacological approaches for ameliorating these deficits. Postmortem studies ...
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Deficits in cognitive control, a core disturbance of schizophrenia, appear to emerge from impaired prefrontal gamma oscillations. Cortical gamma oscillations require strong inhibitory inputs to pyramidal neurons from the parvalbumin basket cell (PVBC) class of GABAergic neurons. Recent findings indicate that schizophrenia is associated with multiple pre- and postsynaptic abnormalities in PVBCs,...
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Patients with schizophrenia have pronounced deficits in memory for events--episodic memory. These deficits severely affect patients' quality of life and functional outcome, and current medications have only a modest effect, making episodic memory an important domain for translational development of clinical trial paradigms. The current article provides a brief review of the significant progress...
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Schizophrenia is a severe psychiatric illness that affects 1% of the world population. It is a brain disease manifesting in disruptions in the normal functioning of the human mind. Although schizophrenia has an evidenced genetic basis, the etiology of this complex disorder remains elusive. In addition to psychotic symptoms, cognitive dysfunction is one of the core symptoms of schizophrenia. Sch...
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ژورنال
عنوان ژورنال: Jurnal Psikiatri Surabaya
سال: 2020
ISSN: 2716-358X,2355-2409
DOI: 10.20473/jps.v9i2.19082